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MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

The effects of Con A,WGA,Zymosan A on membrane potential,cytosolic pH and lysosomal pH of ctltured mouse macrophages were measured with fluorescence method.The results showed all the three kinds of ligands caused macrophage membrane potential hyperpolarization,cytosolic acidification and lysosomal alkalization,but reached their stabilized conditions at different times.The acidification of cytosl might inhibit furgher endocytosis.Alkalization of lysosomes was a basic factor for exocytosis of lysosomal contents.These receptor-mediated induced changes reflected cellular self-regulation and self-protection.

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Citing This Article：

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).