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MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

Radioimmunoassay(RIA)was used to determine the changes of the immunreactivity(ir)of somatostatin(SOM)and calcitonin gene-related peptide (CGRP)in the spinal perfusate of rat induced by electroacupuncture(EA)of different frequencies.The frequency of EA was chosen to be 2,15 and 100 Hz and the spinal perfusate was collected in three periods of 30 min before,during and after EA.The results indicate:(1)low frequency EA(2Hz)increased the spinal SOM-ir level by 39% (P＜0.05)but decreased that of CGRP-ir by 47%(P＜0.05);(2)conversely,15 Hz EA decreased spinal fluid SOM-ir level by 37%(P＜0.05)but increased tha of CGRP ir by 92%(P＜O.05);(3)100 Hz EA behaved like 15 Hz in inhibiting SOM-ir 1evel (P＜0.01),but without effect on CGRP-ir.The above results show that specific frequency is required for peripheral electrical stimulation to activae or suppress the release of spinal neuropeptides SOM and CGRP,a fact that may have clinical implications.

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Citing This Article：

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).