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MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

The level of calcitonin gene related peptide(CGRP)in plasma and pulmonary lavage fluid was tested by radio-immunoassay on intestinal ischemia/reperfusion(I/R)injured rat.The results showed that plasma CGRP after I/R was 161.3% more than control,and 117.8% when pre-treated with platelet activating factor(PM)receptor antagonist SR27417A before injury but no obvious changes were observed in the sham group.Meanwhile,CGRP was reduced by 17.4% in pulmomary lavage fluid in I/R animal and elevated by 97.9% in SR27417A pre-treated animal,compared with normal control.Furthermore,it was demonstrated that CGRP release from lung tissue was enhanced concentration-dependeuly by calcium ionophores A23187 or PAF,as a result of blockage by phospholipase A2 inhibitor p-BPB or SR27417A respectively.In vitro experiment,CGRP in pulmonary lavage fluid was 144.6% more than control when pre treated with SR27417A and 114.6% less than that treated with A23187 only,even 14.8% less than control.

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Citing This Article：

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).