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MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

Using extracellular recording technique,the effects of L-arginine(L-arg),SIN-1 and N-nitro-Larginine(L-NNA)on glutamate-induced dischargn of neamns in CA1 area of hippocapal slices were examined to define the role of L-arg:NO pathway in glutamate induced discharge of hippocaampal neurons and its possible underlying mechanism.The results obtrined are as follow. (1)In response to the application of glutamae(0.5 mmol/L)into the superfusate for l min,the discharge rate of 12 neurons was increased markedly in an epileptiform pattern.(2)The increased discharge induced by glutamae (0.5mmol/L)in 10 neurons was suppressed significantly by appication of L-arg(10 mmol/L)into the superfusate for 2 min.(3)The glutamate-induced increase of discharge in 12 neurons was decreased maredly by superfusing the brain slice with NO donor SIN 1(5 mmol/L)for 1 min.

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Citing This Article：

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).