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A fluorescence histochemical study of uterine eosinophilia induced by anororin in immature rats

Yang Yiqian, Wu Xiaoyun, Ren Hueimin, Zhang Shenggen

Shanghai Institute of Planned Parenthood Research；Shanghai Institute of Physiology, Academia Sinica

Abstract

A fluorescence histochemical demonstration of uterine cositophilia induced by the Anordrin was studied in immature Wistar rats with the following results:
(1) Anordrin induced uterine eosinophilia and a nearly parallel increase in weight. (2) Subcutaneous injection showed much more potent effects than oral administration. (3) After a single injection of Anordrin (100ikg), the induced uterine effects could be noticed in about 24h and thereafter maintained at a high level during the subsequent 2-24 d period which then gradually subsided after 27th day.(4) SIPPR-113, an Anordrin analogue, with lower estrogenicity induced little migration of eosinophils into the uterus and slight increase in uterine weight.

Key words: Uterus;Eosinophil;Anordrin;Estrogenic activity

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Citing This Article：

Yang Yiqian, Wu Xiaoyun, Ren Hueimin, Zhang Shenggen. A fluorescence histochemical study of uterine eosinophilia induced by anororin in immature rats. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).