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Effects of brain ventricular injection of hypertonic/hypotonic NaCl solutions on plasma renin activity and renal sympathetic nerve activity

Zhang Yanling, Chai Xiangshu

Department of Physiology, Shangdong Academy of Medical Science. Jinan, China

Abstract

Injection of hypertonic NaCl solution into 3rd ventricle of the brain markedly
decreases the renal sympathetic nerve activity (RSNA) and plasma renin activity
(PRA). The effects of hypotonic NaCl solution were opposite to those due to
hypertonic NaCl. In either cases of NaCl injection the PRA and RSNA changes
were positively correlative. The effects of hypertonic or hypotonic NaCl injection on PRA were eliminated after a renal denervation. Therefore it appears that renin release due to the change of sodium ion concentration in cerebrospinal fluid is mediated by efferent renal sympathetic nerves.

Key words: Intraventricular injection;Renal sympathetic nervs;Plasma renin

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Citing This Article：

Zhang Yanling, Chai Xiangshu. Effects of brain ventricular injection of hypertonic/hypotonic NaCl solutions on plasma renin activity and renal sympathetic nerve activity. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).