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A study on the decrease of pancreatic amylase and trypsin activities in rat after exposure to gamma irradiation

Xue Baogang, Zhang Yuenxiang, Pan Guozong

Institute of Radiation Medicine, Beijing；Division of Gastroenterology, Beijing, Union Medical College Hospital

Abstract

1.Amylase and trypsin activities decreased significantly after gamma irradiation and were paralleled by a simultaneous decrease of pancreatic weight.
To some extent decrease of enzymatic activities and loss of pancreatic weight were dose-dependent. 2. With the used dosage of radiation, the enzymatic activities in the supernatant of pancreatic tissue homogenate remained unchanged. 3.The carbachol-stimulated amylase release from pancreatic acini :in rat after exposure to radiation was markedly decreased. 4. Electron microscopic study of the pancreatic acini in rat after exposure to radiation showed various. degrees of destruction of acini and reduced formation of zymogen granules.

Key words: Radiation;Amylase;Trypsin;Pancreatic acini;Pancreatic secretion

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Citing This Article：

Xue Baogang, Zhang Yuenxiang, Pan Guozong. A study on the decrease of pancreatic amylase and trypsin activities in rat after exposure to gamma irradiation. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).