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The mechanism of inhibition of anisodamine on platelet aggregation induced by e. Coli endotoxin

Zhu Guangjin, Xu Shuhuai, Xue Quanfu, Chen Huacui

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

Abstract

The platelet aggregation induced by E. coli endotoxin both in vivo and in vitro in rabbit were observed. The platelet level of cAMP was decreased by intervention of E. coli endotoxin in vitro. Anisodamine inhibited the platelet aggregation induced by E. coli endotoxin and increased the level of CAMP. This effect increased cAMP level could be blocked by alprenolol (a #beta#-receptor blockade).

Key words: E. coli endotoxin;Anisodamine;Alprenolol;Cyclic-AMP;PACR

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Citing This Article：

Zhu Guangjin, Xu Shuhuai, Xue Quanfu, Chen Huacui. The mechanism of inhibition of anisodamine on platelet aggregation induced by e. Coli endotoxin. Acta Physiol Sin 1986; 38 (3): (in Chinese with English abstract).