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Changes in pulmonary arterial pressure during acute respiratory distress syndrome caused by injection of oleic acid in rabbits

Ni Hui, Zhang Shangjian, Zhang Rixin, Shen Shang, Yan Chuanhua

Department of Physiology, Nanjing Medical College. Nanjing, Jiangsu, China

Abstract

This paper reports the changes in pulmonary arterial pressure during the acute respiratory distress syndrome caused by oleic acid injection in rabbits. Following intravenous injection of oleic acid the pulmonary vascular resistance was found to be increased markedly while the arterial pressure, heart rate and the cardiac output were lowered. The pulmonary arterial pressure was increased accordingly which showed phasic alterations, i.e., initial rapid rise, relative stable period and a subsequent late increase. Pretreatment with ganglionic blocking agent-hexamethonium as well as“blocker- phentolamine abolished the initial rapid rise of pulmonary arterial pressure following injection of oleic acid. Bilateral severance of sinus nerves or cervical vagus nerves had no effect. Moreover, neither hexamethonium nor phentolamine could block the rise of pulmonary arterial pressure in the late stage. It is thus assumed that the initial rapid rise of pulmonary arterial pressure following injection of oleic acid involves the activities of sympathetic nerves, while its late increase is mainly due to the ensuing anoxia and the relevant factors involved.

Key words: Acute respiratory distress syndrome;Oleic acid;Pulmonary arterial pressure;Pulmonary vascular resistance;Hesamethonium;Phentolamine

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Citing This Article：

Ni Hui, Zhang Shangjian, Zhang Rixin, Shen Shang, Yan Chuanhua. Changes in pulmonary arterial pressure during acute respiratory distress syndrome caused by injection of oleic acid in rabbits. Acta Physiol Sin 1986; 38 (3): (in Chinese with English abstract).