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The hemodynamic effect of distention of the stomach in dogs with normal and stenosed coronary artery

Chen Shiliang, Pan Zhen, Zhu Miaozhang, Zang Yimin

Department of Physiology, Fourth Military Medical College of PLA

Abstract

It has long been known that food intake or distention of the stomach affects cardiovascular function, but the conclusion remains controversial. Previous experiments were made on animals with normal coronary circulation. In this paper, the effect of distention of the stomach was studied in dogs with either normal or stenosed coronary artery. In 22 open-chest mongrel dogs, critical and severe stenosis were produced on left circumflex coronary artery (CX) with a micrometer constrictor. A large balloon was placed into the stomach and inflated with 600 ml of air. The postdistention effect was observed for 30 min. The response to distention of the stomach was biphasic. At the early stage of stomach distention in dogs with normal coronary artery, left circumflex coronary blood flow (Fcx) was increased, mean arterial pressure (Pa) rose, resistance of CX was reduced, and CX vasodilation occurred. All these changes recovered within a quarter to half an hour. In critical coronary stenosis, CX vasodilation occurred first, then followed by a decrease of Fcx, the resistance of distal vascular bed (R2) increased as a result of vasoconstriction. In severe coronary stenosis, at first Fcx was unchanged, but then decreased remarkably, R, R_(2) and the resistance of proximal segment (R_(1)) rose, CX vasoconstriction occurred. It is suggested that postprandial angina pectoris be due to a reduction in coronary blood flow on the basis of coronary stenosis.

Key words: Distention of stomach;Coronary blood flow;Coronary stenosis;Peripheral coronary pressure;Coronary vascular resistance

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Citing This Article：

Chen Shiliang, Pan Zhen, Zhu Miaozhang, Zang Yimin. The hemodynamic effect of distention of the stomach in dogs with normal and stenosed coronary artery. Acta Physiol Sin 1986; 38 (3): (in Chinese with English abstract).