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[Function of intersectin in endocytosis and exocytosis.] [Article in Chinese]

TIAN Chun-Ying, ZHANG Chun-Ling, GU Feng, MA Yong-Jie

Tianjin Medical University Cancer Institute &； Hospital, Tianjin 300060, China； 2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

Intersectin is an evolutionarily conserved multifunctional adaptor protein with multifunctional domains. These domains interact with components of the endocytic and exocytic pathways, such as the clathrin mediating synaptic vesicle recycling, the protein related to endocytosis via caveolae, the with-no-lysine kinases related to the regulation of renal outer medullar potassium, and the Cdc42 mediating exocytic pathway. Recently, the understanding of intersectin function in the pathogenesis of endocrine tumor and many neurodegenerative diseases such as Down syndrome, Alzheimer disease has been deepened. This article reviewed the structure and roles in endocytosis/exocytosis and diseases of intersectin.

Key words: intersectin; endocytosis; exocytosis; clathrin

Received: 2012-01-18　　Accepted: 2012-03-19

Corresponding author: 马勇杰　　E-mail: yongjiemagu@yahoo.com.cn

Citing This Article：

TIAN Chun-Ying, ZHANG Chun-Ling, GU Feng, MA Yong-Jie. [Function of intersectin in endocytosis and exocytosis.] [Article in Chinese] . Acta Physiol Sin 2012; 64 (4): 489-494 (in Chinese with English abstract).