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Effect of intracerebroventricular injection of bombesin on indomethacin induced gastric ulcer in rats

Li Jiyao, Zhang Xijin, Lu Qinghao

Research Laboratory of Digestion and Reproduction, Institute of Basic Medical Sciences, Beijing Medical University. Beijing, China

Abstract

Intracerebroventricularly (i.c.v.) administered bombesin significantly inhibited
the development of gastric ulcer induced by indomethacin in rats in a dose dependent manner. At the same time, bombesin (i.c.v.) also inhibited gastric secretion and increased gastric barrier mucus. These actions may contribute to its protective effect against ulceration. Gastric sympathetic denervation had no effect on ulceration or the protective action of bombesin. While, bilateral vagotomy reduced ulceration significantly. But in the vagotomized rats the protective effect of bombesin. was less than that in the intact animals, and also less than that of vagotomy alone. Intraventricular injection of TRH, a well known vagal center excitator, potentiated the indomethacin induced ulcer and reversed the action of bombesin. These results suggest that bombesin might exert its effect partly through the inhibition on vagal tone. Microinjection of bombesin (0.3ag) into the anterior nucleus or ventromediala nucleus of the hypothalamus could obviously reduce gasaic ulceration. When bombesin in the same dose was injected into the posterior nucleus, no effect was.observed. These results show that both the anterior and the ventromedial nuclei are effective sites of action of bombesin.

Key words: Bombesin;Indomethacin;Gastric ulcer;Hypothalamus;TRH

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Citing This Article：

Li Jiyao, Zhang Xijin, Lu Qinghao. Effect of intracerebroventricular injection of bombesin on indomethacin induced gastric ulcer in rats. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).