Issue Archive

Effect of peanut oil and oleic acid on indomethacin-induced gastric mucosal damage in rats

Guo Yanshi, Yang Shujuan, Wang Chihchun

Research Laboratory in Physiology of Digestion and Reproduction, Institute of Basic Medical Sciences, Beijing Medical College. Beijing, China

Abstract

The effect of peanut oil and oleic acid on indomethacin-induced gastric mucosap damage in rats and the mechanism of action of oleic acid were studied. The results were as follows: (1) Peanut oil 1.0 ml and oleic acid in doses of 0.25, 0.5 or 1.0 ml administered orally inhibited significantly the development of gastric mucosal damage induced by indomethacin and the inhibitory action of oleic acid was dose-dependent. (2) 30% glycerin, ethyl oleate, 5% glucose or 0.1% acetic acid 1.0 ml administered orally had no effect on the development of gastric mucosal damage induced by indomethacin. (3) The action of oleic acid introduced into jejunum directly was similar to that administered orally. (4) Atropine, phentolamine or propranolol had no effect on the cytoprotection of peanut oil. From the above results it is suggested that peanut oil and oleic acid may exert a significant cytoprotective effect on the indomethacin-induced gastric mucosal damage. The action of oleic acid.was resulted neither from its energy supplying action nor via autonomic nerves, but might be related to the gut hormones which were released by the stimulation of oleic oil in the intestine.

Key words: Oleic acid;Peanut oil;Indomethacin;Cytoprotection;Gut hormones

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Guo Yanshi, Yang Shujuan, Wang Chihchun. Effect of peanut oil and oleic acid on indomethacin-induced gastric mucosal damage in rats. Acta Physiol Sin 1985; 37 (3): (in Chinese with English abstract).