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Cytoprotective effect of vegetable oil on stress-induced gastric mucosal damage in rats

Guo Yanshi, Zhang Jianfu

Research Laboratory in Physiology of Digestion and Reproduction, Institute of Basic Medical Science, Beijing Medical College. Beijing, China

Abstract

The effect of vegetable oil on gastric mucosal damage induced by cold-restraint stress in rats was studied. The results were as follows: (1) Peanut oil administered orally in doses of 0.5, 1.0 and 2.0 ml, 3 hours before stress may significantly inhibit the development of gastric mucosal damage, but lower dose (0.25ml) was without effect. (2) The cytoprotective effect of peanut oil administered orally 0.5, 1.5, 2.5 and 3.5 hours before stress was also obvious. (3) Rapseed oil and oleic acid also exerted a significantly cytoprotective effect similar to that of peanut oil, but 30%, glycerin did not. (4) The action of peanut oil introduced into jejunum was the same as that administered orally. (5) Indomcthacin could not abolish the cytoprotection of peanut oil. From the above results it is suggested that vegetable oil may exert a significant cytoprotective effect on stress-induced gastric mucosal damage. This effect might be produced by the fatty acid component of the oil acting at proximal part of the small intestine. The mechanism of this effect remains to be shown, but it does not seem to be mediated by prostaglandins.

Key words: Peanut oil;Fatty acid;Stress ulcer;Cytoprotection;Prostaglandin

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Citing This Article：

Guo Yanshi, Zhang Jianfu. Cytoprotective effect of vegetable oil on stress-induced gastric mucosal damage in rats. Acta Physiol Sin 1985; 37 (2): (in Chinese with English abstract).