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Effect of stimulation of nucleus accumbens and naloxone microinjection on nociceptive unit discharges in the lateral habenular nucleus

Kao Changqing, Wang Shag

Department of Physiology, Bethune Medical College. Changchun, Jilin, China

Abstract

Experiments were carried out on conscious immobilized rats. Stimulation of the nucleus accumbens could strongly inhibit spontaneous as well as the nociceptive discharges of the lateral habenular nucleus units which were excited by noxious stimulation (LHPE). The inhibitory effect might be blocked by intraperitoneal injection of naloxone (6 mg/kg). On the other hand, electrical stimulation of the nucleus accumbens increased the frequency of spontaneous discharges of lateral habenular nucleus units which were inhibited by noxious stimulation (LHPI). Bilateral injection of naloxone (1.8 #mu#g) into the nucleus accumbens increased the frequency of spontaneous discharges of LHPE, but the spontaneous discharges of LHPE were abolished by injection of morphine (15 #mu#g) into bilateral nucleus accumbens. The results mentioned above and their significance in acupuncture analgesia were discussed.

Key words: Nucleus accuinbens;Lateral habenular nucleus;Nociceptive discharges;Naloxomme

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Citing This Article：

Kao Changqing, Wang Shag. Effect of stimulation of nucleus accumbens and naloxone microinjection on nociceptive unit discharges in the lateral habenular nucleus. Acta Physiol Sin 1985; 37 (1): (in Chinese with English abstract).