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The relationship between the activity of phospholipase A_(2) and acute hypoxic pulmonary arterial pressure

Li Huiping, Her Jinlan, Quan Caijuan, Ding Jinsong

Department of Respiratory Internal Medicine, Affiliated Hospital of Guangdong Medical College. Zhangjiang 524001, Guangdong, China

Abstract

The action of phospholipase A_(2) (PLA_(2)) and related inflammatory mediators on the fonnation of hypoxic pulmonary arterial hgnrtension was studied. 30 Sprague-Dawley rats were equally divided into three groups at random: normal control group, hypoic group and the group pretreated with dexamethasone plus hypoxia. The pulmonary arterial pressure (PAP) was measured by inserting a microcatheter into the pulmonary artery.Afer 30 min of hypoxia, the ctivity of PLA_(2), platelet achvating factor (PAF),prostaglandin E_(2) (PGE_(2)) and thromboxane B_(2) (TXB_(2)) were measured in blood and lung tissue, and it was found that the mean pulmonary arterial pressure (mPAP), the PLA2activity, PGE_(2), TXB_(2) and PAF in blood and lung tissue were sighficanily increased; but pretreatment with dexamethasone relieved the changes mentioned above. In hypoxia, a positive correlations was found between the PLA_(2) activity and mPAP, PAF, PGE_(2), TXB_(2) respectively; positive correlations were also found between PAF, PGE_(2), TXB_(2) and mPAP.

Key words: Phospholipase A_(2);Platelet activating factor;Prostaglandin;Hypoxic pulmonary arterial hypertension

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Citing This Article：

Li Huiping, Her Jinlan, Quan Caijuan, Ding Jinsong. The relationship between the activity of phospholipase A_(2) and acute hypoxic pulmonary arterial pressure. Acta Physiol Sin 1997; 49 (6): (in Chinese with English abstract).