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Role of spinal #alpha# adrenoceptor in the inhibition of renal sympathetic nerve activity and natriuresis induced by blood volume expansion in rabbits

Wang Yong, Lin Maozhang, Han Guichun

Department of Physiology, Dalian Medical University. Dalian 116027, Liaoning, China

Abstract

The effect of spinal #alpha# adrenoceptor blockage on the inhibition of renal sympathetic nerve activity (RSNA) and natriuresis induced by blood volume expansion was investigated in anesthetized and bilateral sinoaortic denervated rabbits. In the groups of rabbits with intrathecal injection of #alpha#-adrenoceptor blocker phentolamine or artificial cerebrospinal fluid the inhibition of RSNA induced by blood volume expansion were (-25.4+-5.4)% and (-42.5+-5.2)% respectively (P<0.05). In the groups of rahbits with intrathecal injection of #alpha#_(1) adtenoceptor blocker prazosin or artificial cerebrospinal fluid the inhibition of RSNA induced by blood volume expansion were (-29.3+-6.1)% and (-42.5+-5.2)% respectively (P<0.05). These results suggested that both spinal #alpha# and #alpha#_(1) adrenceptor blockage attenuated the inhibition of RSNA induced by blood volume expansion.

Key words: Spinal #alpha# adrenceptor;Blood volume expansion;Renal sympathetic nerve activity;Natriuresis;Diuresis

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Citing This Article：

Wang Yong, Lin Maozhang, Han Guichun. Role of spinal #alpha# adrenoceptor in the inhibition of renal sympathetic nerve activity and natriuresis induced by blood volume expansion in rabbits. Acta Physiol Sin 1997; 49 (6): (in Chinese with English abstract).