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Effects of hypoxia and anisodamine on products of TXA_(2) and PGI_(2) in coltured intra-pulmonary arteriolar smooth muscle cells

Hu Dehui, Liu Huijun, Ma Chuantao

Laboratory of Cardiovascular Physiology, Hunan Medical University. Changsha 410078, Hunan, China

Abstract

The changes of contents of TXB_(2) and 6-Keto-PGF_(1a) were studied in severely acute hypoxic cultured intra-pulmonary aIteriolar smooth muscle cells (PASMCs) under the action of anisodamine. The results demonstrated that the contents of TXB_(2) and 6-Keto-PGF_(1a) and their ratio were significantly increased in severe acute hypoxic PASMCs'medium. The content of TXB_(2) decreased significantly, but the content of 6-Keto-PGF1a was hardly affected by anisodamine under normoxia and hypoxia. These findings suggest that acute and severe hypoxia results in pulmonare vascular constriction through increased production of PASMCs and liheration of TXA_(2), or PGI_(2), and increased TXA_(2)/PGI_(2) ratio. The latter effect of hypoxia could be prevented by anisodamine, which antagonized theeffect of hypoxia induced pulmonary vasoconstriction.

Key words: TXA_(2);PGI_(2);Hypoxia;Anisodamine;PASMCs;Culture

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Citing This Article：

Hu Dehui, Liu Huijun, Ma Chuantao. Effects of hypoxia and anisodamine on products of TXA_(2) and PGI_(2) in coltured intra-pulmonary arteriolar smooth muscle cells. Acta Physiol Sin 1997; 49 (6): (in Chinese with English abstract).