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Xie Zhongming, Hsieh Chungming, Mao Quanfu, Xu Meihong, Gu Peide

Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center for Research in Human Reproduction. Shanghai 200032, China；Statistical Lamoratory, Peking University. Beijing 100871, China

Abstract

The intrinsic nature of rthymic release of luteinizing hormone (LH) of isolated human and rat anterior pituitare gland reported independently by Macro Gambacciani and Xie in 1987 can be more directly demonstrated by a computer programme of Time Series-HSY Hidden Periodic Analytic Approach for continuous monitoring the LH output of the perfusate from a perfusion system with in vitro anterior pituitary of SD female rat. The results are as follows: (1) Under various reproductive conditions the average frequency (min/cycle) and amplitude (ng/ml) of the intrinsic rhythm of LH release were quite different: In proestrous group the frequency and amplitude were the highest, being intermediate in the ovariectomized group and lowest in the lactation group. (2) The intrinsic rhythm of LH release could be changed by either peptide or steriod hormones. In proestrous group with 30 min of gonadotropin-releasing hormone (GnRH), stimulation would reduce both frequency and amplitude.

Key words: Isolated rat anterior pituitary;Various conditions of reproductive hormone;Intrinsic rhythm of LH release;Time-series analysis

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Citing This Article：

Xie Zhongming, Hsieh Chungming, Mao Quanfu, Xu Meihong, Gu Peide. . Acta Physiol Sin 1997; 49 (6): (in Chinese with English abstract).