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Receptors of monoamine in sympathetic preganglionic neurons of neonatal rat spinal cord in vitro

Cai Shengrong, Wang Liecheng, Kong Dehu, Huang Zhenxin, Ma Ruchun

Department of Physiology, Anhui Medical University. Hefei 230032, Anhui, China；Department of Physioloy, Anhui Chinese Traditional Medical College. Hefei 230038, Anhui, China

Abstract

By means of intracellular recordings from spinal cord slices of neonatal rats in vitro,the effects of 5-hydroxytryptamine (5-HT), nor-adrenaline (NA) and adrenaline (AD)on membrane potential in sympathetic preganglionic neurons (SPN) were observed,in order to clarify whether these neuron contain a single type of the monoamine receptor or in cornbination with more than one type of receptors. The results showed that: (1) 5-HT,NA and AD induced membrane depolarization respectively in 57.11% (16/28), 60%(15/25) and 52.4% (11/21) of SPN. (2) According to the reactions of SPN to the three monoamines, several subtypes of SPN could be divided: those sensitive to all the three monoarnines (3/19), those sensitive to two of them (9/19), those only sensitive to one trpe of monoandnes (4/19) and those insensitive at all (3/19). The significance of coexistence of more than one type of the three monoamines in a single neuron remains to be elucidated.

Key words: 5-hydroxytryptamine;Noradrenaline;Adrenaline;Monoamine;Sympathetic preganglionic neuron

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Citing This Article：

Cai Shengrong, Wang Liecheng, Kong Dehu, Huang Zhenxin, Ma Ruchun. Receptors of monoamine in sympathetic preganglionic neurons of neonatal rat spinal cord in vitro. Acta Physiol Sin 1997; 49 (5): (in Chinese with English abstract).