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Centrally administrated histamine on gastric acid secertion

Zhang Zhifang, Wang Zhuli, Lu Guangqi

Department of Physiology, Sun Yat-Sen University of Medical Sciences. Guangzhou 510089, Guangdong, China

Abstract

The present experiment is undertaken to study the peripheral mechanism of the inhibitory effect of intra third ventricular administration of histamine (HA, icv) on gastric acid secretion. Gastric acid was continuously washed with 37℃ saline by means of a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenpusly by a syringe pump and their effect on pentagastrin-induced [10g/(kg·h), iv] gastric acid secretion was measured. The results were as follows: (1) The inhibitory effect of HA on gastric acid secretion was abolished by subdiaphragmatic vagotomy. (2) The inhibitory effect of HA on gastric acid secretion could be abolished by pretreatment with atropine [0.05 mg/(kg·100 min), iv]. (3) Pretreatment with somatostatin antagonist, cyclo[7-aminoheptanoyl-Phe-D-Trp-Lys-(Bzl)], [2～4 #mu#g/(kg·100 min), iv] could a1so block the inhihitory effect of HA on gastric acid secretion in a dose dependent manner.

Key words: Histamine;Third ventricle;Somatostatin antagonist;Gastric acid secretion;Atropine sulfate

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Citing This Article：

Zhang Zhifang, Wang Zhuli, Lu Guangqi. Centrally administrated histamine on gastric acid secertion. Acta Physiol Sin 1997; 49 (5): (in Chinese with English abstract).