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Immobilization stress induced changes of ventricular electric stability in damaged heart depends on the extent of free radical damage

Bian Jinsong, Wang Youlin, Li Dexing

Department of Pharmacology, Nanjing Medical University. Nanjing 210029, Jiangsu, China

Abstract

Following persistent irnmobilization stress, differences in changes of ventricular electric stability (VES) between normal (Nor) rats and rats with myocardial damage induced by doxorubicin (Dox) were studied and compared. The latencies of arrhythmias due to iwtt aconitine (at a rate of 0.8 #mu#g/min) were significantly shorter in Dox rats than in Nor rats, ie, it was easier for Dox rats to develop axrhythmias. Persistent immobilization stress caused an initial decrease followed by a subsequent increase of VES in Nor rats. However, Dox rats following a 8 h' stress show no significant changes in latency and duration of arrhythmias, in contrast with the shortening of the two indexes in rats only immobilized for 2 h, indicating that the increased VES induced by prolonged stress in Nor rats was eliminated by Dox. Both heart rate and cAMP content in myocAnial tissue of Dox rats show no obvious changes in 2 h' stress, but significantly decreased in 8h' immobilizati0n rats.

Key words: Immobilization;Stress;Arrhythmia;Doxorubicin;aconitine;Free radicals

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Citing This Article：

Bian Jinsong, Wang Youlin, Li Dexing. Immobilization stress induced changes of ventricular electric stability in damaged heart depends on the extent of free radical damage. Acta Physiol Sin 1997; 49 (5): (in Chinese with English abstract).