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Effect of microinjection of angiotensin Ⅱ into subnucleus commissurius of nucleus solitarius tractus on cardiovascular activity in the rabbit

Yang Kun, Ding Hu, Wu Jianhua

Department of Physiology, Faculty of Basic Medical Science, Tongji Medical University. Wuhan, China

Abstract

Microinjection of angiotensin Ⅱ(AⅡ, 4#mu#g) into the subnucleus commissurius
of nucleus solitarius tractus (CNTS) in rabbits under urethane anesthesia caused a marked increase of mean arterial blood pressure and decrease of heart rate. After severing bilateral sinoaortic denervation, the pressor response of AⅡ became more marked, but the heart rate remained unchanged. Microinjection of AⅡ into CNTS did not show any effect on arterial barorefleg sensitivity. The results suggest that it was the vasomotor neurons, but not the cardioaccelerator neurons in the brain stem was affected by AⅡ.

Key words: Subnucleus commissurius of nucleus tractus solitarius;angiotensinⅡ;Nalexone;Arterial baroreflex sensitivity

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Citing This Article：

Yang Kun, Ding Hu, Wu Jianhua. Effect of microinjection of angiotensin Ⅱ into subnucleus commissurius of nucleus solitarius tractus on cardiovascular activity in the rabbit. Acta Physiol Sin 1987; 39 (4): (in Chinese with English abstract).