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Opiate system mediated hypotensive and bradycardiac effect evoked by norepinephrine injected into cnts of rabbits

Ding Hu, Wu Jianhua, Yang Kun

Department of Physiology, Tongji Medical University. Wuhan, China

Abstract

Microinjection of norepinephrine (NE, 30 nmol) into the subnucleus commissuralis of nucleus tractus solitarii (CNTS) of rabbits evoked a decrease of mean arterial pressure (MAP) and heart rate (HR). These effects were attenuated by application of naloxone (3 nmol) on the same area,which by itself showed no effect on MAP and HR. Microinjection of morphine (10 #mu#g) into CNTS also resulted in decreases of MAP and HR and could be reinforced significantly by injection into CNTS of a small amount of NE (5 #mu#mol), which by itself showed little or no effect on MAP and HR. The results suggest that the cardiovascular effect evoked by NE in CNTS may be partly mediated by a depressive opiate system.

Key words: Norepinephrine;Naloxone;Morphine;Subuncleus commissuralis of nucleus tractus solitarii;Microinjection;Blood pressure;Heart rate

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Citing This Article：

Ding Hu, Wu Jianhua, Yang Kun. Opiate system mediated hypotensive and bradycardiac effect evoked by norepinephrine injected into cnts of rabbits. Acta Physiol Sin 1987; 39 (4): (in Chinese with English abstract).