Issue Archive

Observation of cholinergic effect on the postprandial release of neurotensin in man

Chen Shoupo, Cai Qiang, Chen Yuanfang, Lu Guojun

Department of Medicine, Peking union Medical College Hospital, Chinese Academy of Medical Sciences

Abstract

Effect of intramuscular injection of atropine on the mixed meal stimulated
plasma neurotensin-like immunoreactivity (NTLI) levels was studied in the present investigation. The plasma NTLI was measured by radioimmunoassay with Nterminally directed antiserum. Levels of plasma pancreatic polypeptide (PP) were .determined as well. The basal plasma NTLI and PP levels were 15.7±2.4 aad 16.6±9.7 pmol/L、respectively. Like plasma PP ,the levels of NTLI in plasma show a rapid rise (60.7±13.2 pmol/L) 20 min following the meal and then followed by a second rise.(58.8±8.2 pmol/L) 70 min later. Injection of atropine sulphate(1 mg) 20 min before the meal abolished the early but not the late peak. Chewing food only did not increase the levels of plasma NTLI but adequate cephalic vagal stimulation did increase plasma PP level. Thus it appears that a cholinergic non-vagal and a cholinergic mechanism.are involved respectively in the early and in the late phase of release of neurotensin in man. Discrepancies with the results obtained by other authors are discussed.

Key words: Neurotensin;Cholinergic nerve;Atropine;Chewing food

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Chen Shoupo, Cai Qiang, Chen Yuanfang, Lu Guojun. Observation of cholinergic effect on the postprandial release of neurotensin in man. Acta Physiol Sin 1987; 39 (4): (in Chinese with English abstract).