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Effect of lateral hypothalamus injection of trh on gastric acid secretion in rats

Ling Wenhua, Dai Yilong, Li Dongsheng, Ge Zhiheng

Department of Physiology, Nanjing Medical College

Abstract

In the present study the results were as follows: (1) Thyrotropin-releasing
hormone (TRH) injected into the lateral hypothalamic area (LHA) increased
gastric acid output significantly; (2) The increase was not affected by central
administration of phentolamine or metoprolol and gastrin antibody, but completely abolished by atropine; (3) Hypophysectomy or adrenalectomy did not affect the gastric acid response to TRH nor vagotomy; (4) The time course of acid secretion, induced by TRH after celiac ganglionectomy did not show a peak response.The aforementioned results indicate that cholinergic M-receptor in LHA is involved in the central mechanism of acid secretion induced by TRH and the
sympathetic nerve and vagus are the possible efferent pathways.

Key words: Thyrotropin-releasing hormone;LHA injection;Phentolamine;Metoprolol

Received: 　　Accepted:

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Citing This Article：

Ling Wenhua, Dai Yilong, Li Dongsheng, Ge Zhiheng. Effect of lateral hypothalamus injection of trh on gastric acid secretion in rats. Acta Physiol Sin 1987; 39 (4): (in Chinese with English abstract).