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The locus coeruleus modulates the inspiratory inhibition induced by electrical stimulation of the B(o)tzinger complex

Zhang Fayan, Li Yanchun, Xiong Yiqin, Wang Guimin, Li Qin, Song Gang

Department of Physiology, Shandong University of Traditional Chinese Medicine. Jinan 250014；Institute of Physiology, School of Medicine, Shangdong University. Jinaj 250012, China

Abstract

Experiments were done on urethane anesthetized adult rabbits. Long-train electrical stimulation was delivered to the B?tzinger complex(B?t.C) to observe the changes in the peak amplitude of integrated phrenic nerve activity. Then, a long-train electrical stimulation was delivered to the locus coeruleus(LC) or monosodium glutamate was microinjected into the LC . Within a certain period of time, another long-train electrical stimulation was delivered to the B?t.C to observe the responses of phrenic nerve activity. We investigated whether the LC could modulate the inspiratory inhibition induced by electrical stimulation of the B?t.C. The results are as follows: (1) Within a certain period of time after a long-train electrical stimulation applied at the LC, the inspiratory inhibition produced by electrical stimulation at the B?t.C was significantly attenuated.

Key words: Boetzinger complex;Locus coeruleus;modulation;Respiration;Electrical stimulation;Rabbit

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Citing This Article：

Zhang Fayan, Li Yanchun, Xiong Yiqin, Wang Guimin, Li Qin, Song Gang. The locus coeruleus modulates the inspiratory inhibition induced by electrical stimulation of the B(o)tzinger complex. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).