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Chronic intermittent hypoxia decreases acute hypoxic inhibition of voltage-gated potassium channel in rat pulmonary arterial smooth muscle cells

Tang Bi, Tang Ming, Du Yimei, Liu Cnangjin, Hong Zhigang, Luo Hongyan, Hu Xinwu, Song Yuanlong, Xi Jiaoya, Jurgen Hescheler

Department of Physiology, Tongji Medical College of Huazhong University of Science and Technology. Wuhan 430030, China；Department of Geriatrics, the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Wuhan 430022, China；Institute of Neurophysiology, University of Cologne, D-50931 Cologne Germany

Abstract

For determination the ionic mechanisms of the hypoxic acclimatization at the level of channels, male Spradue-Dawley rats were divided into two groups control normoxic group and chronic intrmittent hypoxic group [O_(2) concebtratuib: (10±0.5)%, hypoxia 8h a day]. Using whole cell patch-clamp technique, voltage-gated potassium channel currents [(IK_(v)] wre recorded in freshly isolated pu;monary arterial smooth muscle cells (PASMCs) of rat with acute isolated method.

Key words: Pulmonary artery;Voltage Gated potassium channel;Patch clamp;Hypoxia

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Citing This Article：

Tang Bi, Tang Ming, Du Yimei, Liu Cnangjin, Hong Zhigang, Luo Hongyan, Hu Xinwu, Song Yuanlong, Xi Jiaoya, Jurgen Hescheler. Chronic intermittent hypoxia decreases acute hypoxic inhibition of voltage-gated potassium channel in rat pulmonary arterial smooth muscle cells. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).