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The protective effect of diazoxide on long-term heart preservation

Guo Wei, Shen Yueliang, Chen Yingying, Hu Zhibin, Yan Zhikun, Xia Qiang

Department of Physiology, Zhejiang University School of Medicine；Pelple's Hospital of Zhejiang Province. Hangzhou 310031, China

Abstract

Prolongation of the duration of heart preservation in virto is very important in clinical heart transplantation. Previous studies have shown that mitoxhondrial ATP-sensitive potassium channel [mito K_(ATP)] plays an important role in cardioprotective effect. The purpose of this study was to assess whether the mito K_(ATP) opener diazoxide as an additive to cardioplegia solution could enhance myocardial protecton during long-term hypothermic preservation of the rat heart.

Key words: Diazoxide;Organ preservation;Mitochondria;Heart;Adenosine triphosphate;Potassium channels;Ischemia

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Citing This Article：

Guo Wei, Shen Yueliang, Chen Yingying, Hu Zhibin, Yan Zhikun, Xia Qiang. The protective effect of diazoxide on long-term heart preservation. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).