Issue Archive

High-frequency electrical stimulation of femoral nerve reduces infarct size following myocardial ischemia-reperfusion in rats

Dong Jinghui, Liu Yixian, Zhao Juan, Ma Huijie, Guo Shumei, He Ruirong

Department of Physiology, Institute of Basic Medicine, Hebei Medical University. Shijiazhuang 050017, China

Abstract

The effects of femoral nerve electrostimulation (FNES) on ischemia-reperfused myocardium were examined in the urethaneanesthetized rats to determine whether FNES may provide cardioprotection and to observe the possible mechanism. The area at risk (AR) and infarct area (IA) were determined using Evans blue and nitro-blue tetrazolium staining, respectively. Infarct size (IS) was defined as 100 × IA/AR (%). The results are as follows: (1) During 30 min myocardial ischemia and subsequent 120 min reperfusion,the myocardial infarct size occupied (54.96±0.82)% of the area at risk.

Key words: Ischemia-reperfusion;Electrostimulation;Opioid;Naloxone;Glibenclamide

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Dong Jinghui, Liu Yixian, Zhao Juan, Ma Huijie, Guo Shumei, He Ruirong. High-frequency electrical stimulation of femoral nerve reduces infarct size following myocardial ischemia-reperfusion in rats. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).