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Effects of intraventricular and epicardial application of adenosine on electrical activity of medullary pgl neurons

Ma Xiuying, Fan Zhenzhong, He Ruirong

Department of Physiology, Institute of Basic Medicine, Hebei Medical University. Shijiazhuang 050017, Hebei, China

Abstract

The effects of intraventricular injection and epicardial application of adenosine on spontaneous electrical activity of nucleus paragigantocellularis lateralis (PGL) neurons in rostral ventrolateral medulla(RVLM) were examined in 35 anesthetized rats with sinoaortic denervation and vagotomy. The results obtained were as follows: (1) The sPOntaneous discharge of 121 PGL neurons (mean discharge rate: 22.5+-1.9 spikes/s) were recorded in 35 rats. (2) In resp0nse to intraventricular injection of adenosine (0.5 #mu#mol/kg), mean arterial pressure (MAP) was initially increased by 1.7+-0.2 kPa(P<0.001) and subsequently decreased by 4.6+-0.5 kPa(P<0.001), while the heart rate (HR) was decreased by 126.5+-12.3 bpm (P<0.001). Of 35 PGL spontaneous discharge units responsive to intraventricu1ar injection of adenosine, 30 showed an average increase from 21.9+-2.6 to 29.2+-3.4 spikes/s (P<0.001), 3 with no change, while 2 with a decrease.

Key words: Adenosine;Adenosine receptors;Cardiac sympathetic afferents;Rostral ventrolateral medulla

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Citing This Article：

Ma Xiuying, Fan Zhenzhong, He Ruirong. Effects of intraventricular and epicardial application of adenosine on electrical activity of medullary pgl neurons. Acta Physiol Sin 1997; 49 (5): (in Chinese with English abstract).