Effects of hypoxia on myoglobin in cultured rat myocytes
Chai Dan, Zhou Zhaonian
Institute of Physiology, Chinese Academy of Sciences. Shanghai 200031, China
Abstract
The effects of hyoxia and reoxygenation on myoglobin (Mb), cAMP, myocardial contractility and the effects of theophylline (an inhibitor of phosphodiesterase), procaine (an inhibitor of SR calcium release) on Mb expression were studied in cultured myocytes under hypoxic condition. Our results showed that hypoxia increased the Mb expression,but decreased cAMP and myocardial contractility. All these effects of hypoxia were recovered upon reoxygenation. The increase of Mb expression requires the participation of intracellular calcium and cAMP.
Key words: Hypoxia;Reoxygenation;Cultued myocyte;Myoglobin;cAMP;Mycardial contractility
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Citing This Article：
Chai Dan, Zhou Zhaonian. Effects of hypoxia on myoglobin in cultured rat myocytes. Acta Physiol Sin 1997; 49 (5): (in Chinese with English abstract).
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