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Changes of endogenous opioid peptides content in rpgl during acupuncture analgesia

Zhou Li, Jiang Jianwei, Wu Gencheng, Cao Xiaoding

Department of Neurobiology, Shanghai Medical University. Shanghai 200032, China

Abstract

By push-pull perfusion technique and RIA of neuro-peptides，it was found that
after 20 minutes' electroacupunture (EA)，the release of LEK from the RPGL in the EA group was significantly higher than that in the control group (P<0.05). The release of #beta#-EP from the RPGL in the EA group with higher efficacy was significantly higher than that in the control group (P<0.05),but no significant changes were found in the EA group with lower efficacy. There was a positive correlation between the changes of release of LEK or #beta#-EP and the increase of pain threshold.The release of DynA_(1-13) tends to show a barely significant extent(P>0.05).The results indicate that acupuncture analgesia is able to increase the release of LEK and #beta#-EP in the RPGL.

Key words: Leu-enkephalin;#beta#-endorphin;Dynorphin A_(1-13);Electroacupuncture analgesia;Push-pull perfusion;Nucleus reticularis paragigantocellularis lateralis

Received: 　　Accepted:

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Citing This Article：

Zhou Li, Jiang Jianwei, Wu Gencheng, Cao Xiaoding. Changes of endogenous opioid peptides content in rpgl during acupuncture analgesia. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).