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Hemodynamic effects of renal interoreceptor and afferent nerve stimulation in rabbit

Ma Ge, Ho Shiuyong

Department of Physiology, Institute of Basic Medicine, Hebei Medical College. Hebei, China

Abstract

Hemodynamic effects of renal mechano- and chemoreceptor activation and afferent renal nerve stimulation were observed in 39 anesthetized rabbits. The. mean arterial pressure (MAP) and heart rate (HR) were decreased following elevation of ureteral pressure (13-22 mmHg), and retrograde perfusion of NaCl (1.0 mol/L) or KCl (0.15 mol/L) into pelvis via ureter route. The decrease in MAP was enhanced by sinoarotic denervation. HR, MAP, mesentery arterial perfusion pressure (MPP), hindlimb arterial perfusion pressure (HI.PP), left ventricular pressure (LVP), left ventricular dp/dtmat (LV dp/dt,nv,e), cardiac output (CO) and total peripheral resistance (TPR) were decreased during electrical stimulation of afferent renal nerve. By sinoaortic denervation, the aforementioned hemodynamic parameters, except HR, CO and TPR, were reduced more markedly by electric stimulation of afferent renal nerves. Therefore it appears that sinoaortic depressor reflex plays a buffer role in the cardiovascular responses to the stimulation of afferent renal nerves.

Key words: Renal mechanoreceptor;Renal chemoreceptor;Afferent renal nerve hemodynamics sinus nerve;Depressor nerve;;

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Citing This Article：

Ma Ge, Ho Shiuyong. Hemodynamic effects of renal interoreceptor and afferent nerve stimulation in rabbit. Acta Physiol Sin 1990; 42 (3): (in Chinese with English abstract).