ISSN 0371-0874, CN 31-1352/Q

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Effects of lesion and stimulation of hypothalamic arculte nucleus region on leu-enkephalin, dopamine and norepinephrine contents in rat brain and spinal cord

Zhu Mongyang, Gu Xuandi, Zhang Jianwei, Zhang Dexiu

Department of Biochemistry,Medical College. Suzhou, China

Abstract

In rats treated neonatally with monosodium glutamate (MSG) the leu-enkephalin (LEK) and norepinephrine (NE) contents in the brain and spinal cord did not
change obviously, but the dopamine (DA) content of the telencephalon increased
significantly, as compared with the control. After hypothalamic arcuate nucleus
(ARC) stimulation NE content in the spinal cord was significantly higher than that of the control. The results suggest that the ARC may have a catatonic inhibition.on dopaminergic system of the telencephalon, and the descending norepinephrinergic system may play an important role in the ARC stimulationnduced analgesia.

Key words: Hypothalamic arcuate nucleus;Monosodium glutamate;Enkephalin;Dopamine;Norepinephrine

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Citing This Article:

Zhu Mongyang, Gu Xuandi, Zhang Jianwei, Zhang Dexiu. Effects of lesion and stimulation of hypothalamic arculte nucleus region on leu-enkephalin, dopamine and norepinephrine contents in rat brain and spinal cord. Acta Physiol Sin 1987; 39 (2): (in Chinese with English abstract).