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The relation between adaptive cytoprotection and gasiric mucus-bicarbonate barrier

Wang Jianying, Wang Chih Chun

Research Laboratory in Physiology of Digestion and Reproduction, Institute of Basic Medical Sciences, Beijing Medical University. Beijing, China

Abstract

This study was performed to determine the relation between the adaptive
cytoprotection observed by natural and exogenous mild irritants and the mitcus-
bicarbonate secretion in the rat's stomach. Mild irritants, pepsin 150 U in 0.lmol/L HCl and 20% ethanol given intragastrically, markedly increased the secretion of mucus in a dose dependent manner. After a single administration, the action lasted 1 h. This increase of mucus secretion could be abolished by indomethacin, an inhibitor of PG synthesis, but could be restored by exogenously applied PGE_(2). Diamox, an inhibitor of carbonic anhydrase, blocked partially the cytoprotection produced by the mild irritants. These results indicate that the natural and exogenous mild irritants could prevent the gastric necrosis, at least partly through the increase of mucus and bicarbonate secretion mediated by endogenous prostaglandins.

Key words: Adaptive cytoprotection;Gastric mucus;Bicarbonate;Pepsin

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Citing This Article：

Wang Jianying, Wang Chih Chun. The relation between adaptive cytoprotection and gasiric mucus-bicarbonate barrier. Acta Physiol Sin 1987; 39 (2): (in Chinese with English abstract).