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Interaction between renal nerve afferent stimulation-produced depressor response and carotic sinus baroreflex

Pan Jinyun, Tan Lining, Chen Yuhuai, Zhan Chengyang

Department of Physiology, Sun Yat-Sen University of Medical Sciences. Guangzhou, China

Abstract

In anesthetized rabbits the fall in arterial blood pressure was dependent upon
certain voltage and frequency of stimulation of the peripheral end of the renal nerve.In rabbits with vascularly isolated carotid sinuses and aortic nerve cut, the depressor responses to afferent stimulation of renal nerve were progressively diminished as intrasinus pressure (ISP) was elevated stepwise. At seven ISP levels between 45 and 135 mmHg, mean arterial pressure (.MAP) was plotted against ISP to obtain the ISP-MAP relationship before and during afferent stimulation of renal nerve. Afferent stimulation of renal nerve significantly decreased the slope of ISP-MAP relationship between 75 and 105 mmHg ISP and the range of 1SP dependent MAP.These results suggest that(1) the depressor responses to afferent stimulation of renal nerve is modulated by carotid baroreceptor input, varying inversely with the ISP level; and (2) carotid sinus baroreflex sensitivity is greatly decreased by afferent stimulation of renal nerve.

Key words: Arterial blood pressure;Carotid sinus baroreflex;Afferent of renal nerve

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Citing This Article：

Pan Jinyun, Tan Lining, Chen Yuhuai, Zhan Chengyang. Interaction between renal nerve afferent stimulation-produced depressor response and carotic sinus baroreflex. Acta Physiol Sin 1987; 39 (2): (in Chinese with English abstract).