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Changes of discharge rate and pattern of 5-hydroxytrypamine neurons of dorsal raphe nucleus in a rat model of Parkinson's disease

Chu Yuxia, Liu Jian, Feng Jie, Wang Yong, Zhang Qiao Jun, Li Qiang

Department of Physiology, School of Medicine. Xi'an Jiao Tong University；Key Laboratory of Enviorment and Genes Related to Disease. Xi'an 710061, China；Department of Neurology, the Second Hospital, Xi'an Jiao Tong University. Xi'an 710004, China

Abstract

In the present study, changes of the neuronal activity of 5-hydroxytrypamine (5-HT) neurons of dorsal raphe nucleus (DRN) in a rat model of Parkinson's disease (PD) were investigated with glass microelectrode recording. The results showed that the discharge rates of 5-HT neurons in control and PD rats were (1.61±0.56) Hz and (2.61±1.97) Hz, respectively.

Key words: Parkinson's disease;;Dorsal raphe nucleus;5-hydroxytrypamine;6-hydroxydopamine;Electrophysiology

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Citing This Article：

Chu Yuxia, Liu Jian, Feng Jie, Wang Yong, Zhang Qiao Jun, Li Qiang. Changes of discharge rate and pattern of 5-hydroxytrypamine neurons of dorsal raphe nucleus in a rat model of Parkinson's disease. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).