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Acute nerve injury induces long-term potentiation of C-fiber evoked field Potentials in spinal dorsal horn of intact rat

Zhang Hongmei, Zhou Lijun, Hu Xiaodong, Hu Nengwei, Zhang Tong, Liu Xianguo

Department of Physiology, Zhangshan Medical School of Sun Yat-Sen University. Guangzhou 510089, China

Abstract

Nerve injury produces a long lasting neuropathic pain, manifested as allodynia, a decrease in pain threshold and hyperalgesia, an increase in response to noxious stimuli. The mechanism underlying the lasting abnormal pain is not well understood. Our previous works have shown that electrical tetanic stimulation of the sciatic nerve induces long-term potentiation (LTP) of C-fiber evoked field potentials in the spinal dorsal horn, which is considered as a synaptic model of pathlogical pain. In the present study we tested if nerve injury, which is proved to produce neuropathic pain, induced the spinal LTP in intact rats.

Key words: Long-term potentiation;C- fiber;Spinal dorsal horn;Nerve injury;Neuropathic pain

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Citing This Article：

Zhang Hongmei, Zhou Lijun, Hu Xiaodong, Hu Nengwei, Zhang Tong, Liu Xianguo. Acute nerve injury induces long-term potentiation of C-fiber evoked field Potentials in spinal dorsal horn of intact rat. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).