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Dynamic changes of heme oxygenase-1 protein and mRNA in the brains of rats with experimental allergic encephalomyelitis

Tan Guojun, Zhu Yifei, Cao Cuifang, Zhao Xiaoyun, Ma Changsheng, Yang Tianzhu

Department of Neurology, the 2nd Hospital of Hebei Medical Univeristy. Shijiazhuang 050000, China；People's Hospital of Hebei Province. Shijiazhuang 050000, China；Department of Neurobiology, Hebei Medical University. . Shijiazhuang 050000, China

Abstract

In order to ivestigate the role of heme oxygenase-1 (HO-1) in the molecular mechanism of experimental allergic encephalomyelitis (EAE), Which was induced by guinea pig spinal cord homogenate+complete freund adjuvant on Wistar rats, We observed the gene of HO-1 and its protein expression with reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry 1,7,14 and 21 d after EAE induction in rats.

Key words: neurobiology;Encephalomyelitis;Reverse transcriptase polymerase chain reaction;Heme oxygenase;Subfornicla organ

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Citing This Article：

Tan Guojun, Zhu Yifei, Cao Cuifang, Zhao Xiaoyun, Ma Changsheng, Yang Tianzhu. Dynamic changes of heme oxygenase-1 protein and mRNA in the brains of rats with experimental allergic encephalomyelitis. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).