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Regulation of G protein-coupled receptor kinase 5 mRNA and protein level in rat brain by addictive drugs

Zhu Min, Fan Xueliang, Yang Weilin, Jiang Yan, Ma Lan

Pharmacological Research Center, Shanghai Medical College, Fudan University, State Key Lab of Medical Neurlbiology, Fudan University. Shanghai 200032, China

Abstract

G protein-coupled receptor kinase 5 (GRK5) plans in important role in the regulation of GPCR-transduced signals. Our previous study showed that acute administration of morphine could significantly increase GRK5 m RNA level in the cerebral cortex and hippocampus of the rat brain.

Key words: Morphine;Heroine;Cocaine;G protein-coupled receptor kinase;Addiction

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Citing This Article：

Zhu Min, Fan Xueliang, Yang Weilin, Jiang Yan, Ma Lan. Regulation of G protein-coupled receptor kinase 5 mRNA and protein level in rat brain by addictive drugs. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).