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Dynamic changes in focal adhesion kinase during cell migration induced bybFGF and the significance

Liang Guangbo, Zhang Guoping, Jin Huiming, Qian Ruizhe

Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University. Shanghai 200032, China

Abstract

Cell migration plays an important role in repair of injury, angiogenesis, cancer metastasis and so on. In this paper the effects of basic fibroblast growth factor (bFGF) of different concentrations on ECV-304 cell migration, and the dynamic changes in focal adhesion kinase (FAK) were observed. The relationship between FAK and cell migration induced by bFGF was studied. A ECV-304 cell scratch wound model was established and the images of cell migration were quantitatively measured using a computer-assisted videomicroscopic system.

Key words: Migration;FAK;bFGF;integrin #alpha#3

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Citing This Article：

Liang Guangbo, Zhang Guoping, Jin Huiming, Qian Ruizhe. Dynamic changes in focal adhesion kinase during cell migration induced bybFGF and the significance. Acta Physiol Sin 2004; 56 (4): (in Chinese with English abstract).