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Effects of etomidate on local synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord

Li Zhen, Luo Ceng, Sun Yanyan, Chen Jun

Institute of Neuroscience, Fourth Military Medical University. Xi'an 710032, China

Abstract

By using blind spinal slice whole-cell patch-clamp technique, we observed the influence of etomidate (ET) on synaptic transmission in substantia gelatinosa neurous of the adult rat spinal core. Male sdult Sprague-Dawley rats (7-8 weejs old) were anaesthetized with urethane (1.2g/kg. i. p.), and the lumbosacral laminectomy was performed. The Lumbosacral spinal cord (L1-S3) was removed and placed in preoxygenated Krebs solution at 1-3℃.

Key words: Etomidate;Spinal cord;Substantia gelatinosa;Synaptic transmission

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Citing This Article：

Li Zhen, Luo Ceng, Sun Yanyan, Chen Jun. Effects of etomidate on local synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. Acta Physiol Sin 2004; 56 (3): (in Chinese with English abstract).