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Fibronectin upregulates catalase gene expression in rabbit bronchial epithelial cells

Xiang Yang, Qin Xiaoqun, Guan Chaxiang, Zhang Changqing, Luo Ziqiang, Sun Xiuhong

Department of Physiology, XiangYa Medical School, University of South-Central China. Changsha 410078, China

Abstract

We have preciously shown that the binding of integrins with extracellular matrix component fibronectin (Fn) can improve the ability of bronchial epithelial cells (BECs) in resisting oxidnat injury by up-regulating the activity of catalase and increasing the content of GSH. However, the molecular mechanism of its signaling pathway of this protection is still unclear.

Key words: bronchial epithelial cells;fibronectin;integrin;Catalase

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Citing This Article：

Xiang Yang, Qin Xiaoqun, Guan Chaxiang, Zhang Changqing, Luo Ziqiang, Sun Xiuhong. Fibronectin upregulates catalase gene expression in rabbit bronchial epithelial cells. Acta Physiol Sin 2004; 56 (3): (in Chinese with English abstract).