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Effect of c-myb on hCG-induced testosterone secretion in isolated rat Leydig cells

Xiao Aijiao, Wang Jinglei, Fang Lian, Kuang Haibin

Department of Physiology, Jiangxi Medical College. Nanchang 330006, China

Abstract

The present study was carried out to investigate the effect of antisense c-myb oligodeoxynucleotides (ODN) on hCG-induced testosterone secretion in isolated rat Leydig cells. The eddects of cAMP, Ca~(2+) and cycloheximide (CYX) on c-Myb protein expression and testosterone secretion were also observed. The results showed that antisense c-myb ODN inhibited hCG-induced testosterone secretion of isolated rat Leyding cells in a dose-dependent manner.

Key words: Leydig cells;c-myb;Antisense oligodeoxynucleotides;Testosterone

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Citing This Article：

Xiao Aijiao, Wang Jinglei, Fang Lian, Kuang Haibin. Effect of c-myb on hCG-induced testosterone secretion in isolated rat Leydig cells. Acta Physiol Sin 2004; 56 (3): (in Chinese with English abstract).