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Vasonatrin peptide attenuates the enhancement of electrically-induced intracellular calcium transient by isoproterenol in rat cardiac myocytes

Guo Haitao, Zhu Miaozhang, Zhang, Ronghuai, Bi Hui, Zhang Bo, Zhang Haifeng, Yu Jun, Lu Shunyan

Department of Physioloy and, Department of Geriatrics of Xijing Hospital, Fourth Military Medical University. Xi'an 710032, China

Abstract

The purpose of this study was to investigate the effects of vasonatrin peptide (VNP) on electrically-induced intracellular calcium [Ca~(2+)] transient and mechanism of the effect in the cardiac myocytes. The [Ca~(2+)] transient was measured with a fluoremetric method. The effects of HS-142-1,8-Br-cGMP and methylene blue (MB) on [Ca~(2+)] transient in cardiac myocytes were also determined. Isoproterenol (Iso) at 10~(-10)-10~(-6) mol/L augmented electrically-induced [Ca~(2+)], transient dose-dependently.

Key words: Vasonatrin peptide;Cardiac myocytes;Cyclic GMP;Methylene blue;Intracellular Calcium transient

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Citing This Article：

Guo Haitao, Zhu Miaozhang, Zhang, Ronghuai, Bi Hui, Zhang Bo, Zhang Haifeng, Yu Jun, Lu Shunyan. Vasonatrin peptide attenuates the enhancement of electrically-induced intracellular calcium transient by isoproterenol in rat cardiac myocytes. Acta Physiol Sin 2004; 56 (3): (in Chinese with English abstract).