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Effect of microinjection of atrial natriuretic peptide into the paraventricular nucleus on baroreflex sensitivity in conscious rats

Jiang Haiying, Jin Qinghua, Li Yingjun, Xu Dongyuan, Jin Yuanzhe, Jin Xiuji

Department of Physiology, Medical School of Yanbian University.Yanji 133000,Jilin

Abstract

The role of atrial natriuretic peptide (ANP) in the central regulation of the circulation is known to be as a neurotransmitter or a neuromodulator, but its actions on baroreceptor reflex function are not resolved. The present study examined the role of ANP(6, 60ng/0.2#mu#l) by direct microinjection into the hypothalamic paraventricular nucleus (PVN) in conscious rats. OPC-21268(0.45#mu#g/3#mu#l), an antagonist of the V_(1) receptor, was microinjected into the lateral ventricle to examine whether the effect of ANP on baroreflex sensitivity is mediated by vasopressin(VP). ANP significantly increased the baroreflex sensitivity, and OPC-21268 attenuated the increase of baroreflex sensitivity induced by ANP. Intravenous injections of ANP（60ng/0.04ml） did not affect baroreflex sensitivity. These results suggest that ANP in the PVN may produce a facilitative effect on baroreflex, and the effect may be via, at least in part, the central vasopressin.

Key words: atrial natriuretic peptide;Paraventricular nucleus;baroreflex;Vasopressin

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Citing This Article：

Jiang Haiying, Jin Qinghua, Li Yingjun, Xu Dongyuan, Jin Yuanzhe, Jin Xiuji. Effect of microinjection of atrial natriuretic peptide into the paraventricular nucleus on baroreflex sensitivity in conscious rats. Acta Physiol Sin 2005; 57 (2): (in Chinese with English abstract).