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Different firing patterns induced by veratridine and aconitine in injured dorsal root ganglion neurons

Duan Jianhong, Xing Junling, Yang Jing, Hu Sanjue

Institute of Neuroscience,The Fourth Military Medical University.Xi'an 710032,Shaanxi

Abstract

Ectopic spontaneous activity originated from the injured dorsal root ganglion (DRG) neurons in rats was recorded through single dorsal root fiber. The firing patterns induced by veratridine and aconitine, inhibitors of inactivation gate of sodium channel operating on different binding sites, were compared. In the same neuron, veratridine (1.5--5.0 #mu#mol/L) caused slow wave oscillations of interspike intervals (ISIs), while aconitine (10--200 #mu#mol/L) caused tonic firing. Moreover, even if the background firing patterns were various and the reagent concentrations used were different, veratridine and aconitine still induced slow wave oscillations and tonic firing patterns, respectively. The results suggest that veratridine and aconitine induce different firing patterns in injured DRG neurons, which may relate to their inhibitory effects on different binding sites of the sodium channel.

Key words: dorsal root ganglion;firing patterns;veratridine;aconitine;sodium channels

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Citing This Article：

Duan Jianhong, Xing Junling, Yang Jing, Hu Sanjue. Different firing patterns induced by veratridine and aconitine in injured dorsal root ganglion neurons. Acta Physiol Sin 2005; 57 (2): (in Chinese with English abstract).