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Effect of removal of the adventitia on vascular remodeling and vasoconstriction in rabbits

MU Hua Mng, ZHU Zhi Mug, WANG Hai Yan, WANG Li Juan

Department of Hypertension ； Endocrinology，Chongqing Hypertension Institut Daping Hospital Third Military Medical University，Chongqing 400042

Abstract

The aim of the present stu勿was to investigate the effect of removal of the adventitia on vascular remodeling and vasoconstriction of the carotid artery in New Zealand rabbit .Adventitia of carotid artery was re-
moved mechanically .The histology，morphology and reactivity of the carotid artery was observed妙i m munohistochemistry and measurement of carotid ring tension immediately，1 week and 2 weeks after removal of the adventitia .No damage of intima and media was observed after removing the adventitia.Removal of the adventitia caused a remarkable proliferation of the vascular media and formed the neointima .Compared with the control ring，notepinephrine(NE)一induced vasocontraction in adventitia一denuded carotid artery was significantly reduced immediately and 1 week after the operation(P<0. 05).Adventitia removal promoted the neointima formation and decreased vasoconstriction of the carotid artery，indicating that the adventitia is involved in the regulation of vascular remodeling and vasoconstriction.

Key words: adventitia;carotid artery;rabbit

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Citing This Article：

MU Hua Mng, ZHU Zhi Mug, WANG Hai Yan, WANG Li Juan. Effect of removal of the adventitia on vascular remodeling and vasoconstriction in rabbits. Acta Physiol Sin 2003; 55 (3): (in Chinese with English abstract).