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Epileptiform activity of the anterior dorsal hippocampal netmrk induced by acute tetanization of the right posterior dorsal hippocampus of the rat

WANG Weir Ting, Han Dan, ZOU ZU Yu, ZENG June

Department of Physiology Pathology and Pathophysiology, Medical College, Wuhan Univetsity, Wuhan 430071

Abstract

The purpose of the present work was to stu勿the role of unilateral hippocampal neural network in hippocampal epileptogenesis and its cellular mechanisms. Experiments were performed on 45 Sprague- Dawley adult rats .Acute tetanization(60 Hz，2s，0.4一0. 6 mA) of the right posterior dorsal hippocampus(ATPDH) was used to induce hippocampal epilepsy .The single unit discharges and the depth electrographs were synchronously recorded with a glass microelectrode and a pair of stainless concentric electrodes in the psilateral anterior dorsal hippoca mpus(HPC).The results demonstrated that:(1)some primary unit after discharges were synchronized with electrographic after discharges in the anterior dorsal HPC network after eight or nine tetanic trains were administered.Others desynchronized with 5一90 Hz primary depth electrographic after discharges;(2) primary electrographic after discharges were driven by primary unit after discharges in the anterior dorsal HPC;(3) pri
mary unit after discharges were induced by brief primary electrographic after discharges;and(4) plasticity of primary electrographic after discharges and inhibition of single neuron firing were induced by repetitive ATPDH .The
results suggest that hippocampal pathophysiologic network along the temporal-septal axis of the HPC is re-estab lished by the repetitive ATPDH .There are plastic interactions between single neurons and its network during this re- establishment，which may be involved in the generation of“seizure oscillation".Over activation of an intrinsic inhibition of the HPC along its temporal-septal axis might be involved in hippocampal network epileptogenesis.

Key words: electroencephalography;single unit discharges;neural networks;tetanus;Hippocampus;;

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Citing This Article：

WANG Weir Ting, Han Dan, ZOU ZU Yu, ZENG June. Epileptiform activity of the anterior dorsal hippocampal netmrk induced by acute tetanization of the right posterior dorsal hippocampus of the rat. Acta Physiol Sin 2003; 55 (3): (in Chinese with English abstract).